Gedeon Richter, Гропринозин, Groprinozin 500 mg, 50 шт

€15.49
Weight (kg): 0.10

Pharmacological group

Antiviral drugs for systemic use.

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UKUSAEUBUSTWaistHips
XS 8 4 34 31/32 23/24 33/34
S 10 6 36 33/34 25/26 35/36
M 12 8 38 35/36 27/28 37/38
L 12 8 38 35/36 27/28 37/38
XL 10 6 36 33/34 25/26 35/36

Pharmacological.

Groprinosin ® is an antiviral agent with immunomodulating properties. The drug normalizes (in the individual norm) the deficiency or dysfunction of cellular immunity, inducing maturation and differentiation of T-lymphocytes and T1-helper cells, potentiating the induction of lymphoproliferative responses in mitogen or antigen-active cells. Inosine pranobex models the cytotoxicity of T-lymphocytes and natural killer cells, the function of T8-suppressors and T4-helper cells, and also increases the amount of immunoglobulin G and additional surface markers of the compliment. The drug enhances the synthesis of interleukin-1 (IL-1) and the synthesis of interleukin-2 (IL-2), regulating the expression of IL-2 receptors.

Inosine pranobex significantly increases the secretion of endogenous gamma-interferon and reduces the production of interleukin-4 in the body. Inosine pranobex enhances the action of neutrophils, chemotaxis and phagocytosis of monocytes and macrophages.

Inosine pranobex suppresses virus synthesis by embedding inosine-orotic acid in the polyribosomes of the virus-infected cell and inhibits the attachment of adenylic acid to viral mRNA.

Pharmacokinetics.

Suction When administered orally, inosine pranobex is rapidly and completely absorbed (≥ 90%) in the gastrointestinal tract and enters the blood.

Distribution. When the drug and its components were administered to animals, the material labeled with a radioactive isotope, manifested in such organs (in decreasing order of specific activity): kidneys, lungs, liver, heart, spleen, testicles, pancreas, brain and skeletal muscles.

Metabolism. After ingestion of 1 g of inosine pranobex labeled with a radioactive isotope, such plasma levels were found in humans for 1-dimethylamino-2-propanol and 4-acetamido benzoic acid, respectively, 3.7 µg / ml (2:00) and 9.4 µg / ml (1:00). During human tolerance studies, the maximum increase in uric acid level after a dose, as an indicator of inosine in the preparation, is not linear and may vary by up to 10% within 1–3 hours.

Conclusion. Daily excretion with urine of 4-acetamido-benzoic acid and its main metabolite under equilibrium conditions at a dose of 4 g per day was approximately 85% of the dose taken. 95% of radioactivity from 1-dimethylamino-2-propanol in the urine was recovered in unchanged form of 1-dimethylamino-2-propanol and its metabolite (N-oxide). The half-life is 3.5 hours for 1-dimethylamino-2-propanol and 50 minutes for 4-acetamido benzoic acid. The main metabolites of inosine pranobex in humans is the N-oxide for 1-dimethylamino-2-propanol and o-acylglucuronide for

4-acetamidobenzoic acid. Since the inosine molecule is metabolized by biodegradation of purine into uric acid, experiments with inosine pranobex labeled with a radioactive isotope are not informative in humans. In animals, up to 70% of inosine pranobex administered can be excreted in the urine in the form of uric acid after oral administration of the tablet form, and the rest in the form of the usual metabolites, xanthine and hypoxanthine.

Bioavailability. The determination in the urine in the equilibrium state of 4-acetamido-benzoic acid and its metabolite was> 90% of the expected values ​​of the solution. definition

1-dimethylamino-2-propanol and its metabolite was> 76%. The plasma AUC values ​​of 1-dimethylamino-2-propanol were ≥ 88%, 4-acetamido benzoic acid ≥ 77.

testimony

Viral infections caused by herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, measles virus, mumps virus, including in patients with immunodeficiency states;

viral respiratory infections;

human papillomavirus infection of the skin and mucous membranes: genital warts, human papillomavirus infection of the vulva, vagina and cervix (as part of combination therapy);

acute viral encephalitis (as part of complex therapy);

viral hepatitis (as part of complex therapy);

subacute sclerosing panencephalitis (as part of complex therapy).

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Data sheet

Used in/for
Colds, flu
Release form
Pills
Intended for
Universal
Country and URL
Mozazon-tabletki.ua

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