Abz, Ибупрофен 2% сок, Ibuprofen AbZ 2% Saft, 100ml

EAN: 07013810
Weight (kg): 0.10

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

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XS 8 4 34 31/32 23/24 33/34
S 10 6 36 33/34 25/26 35/36
M 12 8 38 35/36 27/28 37/38
L 12 8 38 35/36 27/28 37/38
XL 10 6 36 33/34 25/26 35/36

Non-selectively inhibits COX-1 and COX-2, reduces the synthesis of PG. The anti-inflammatory effect is associated with a decrease in vascular permeability, improved microcirculation, a decrease in the release of inflammatory mediators from the cells (PG, kinins, LT) and the suppression of the energy supply of the inflammatory process. The analgesic effect is due to a decrease in the intensity of inflammation, a decrease in the production of bradykinin and its algogenicity. In rheumatoid arthritis, it mainly affects the exudative and, in part, the proliferative components of the inflammatory response, has a rapid and pronounced analgesic effect, reduces swelling, morning stiffness and limited mobility in the joints. A decrease in the excitability of the heat-regulating centers of the diencephalon results in an antipyretic effect. The severity of the antipyretic effect depends on the initial body temperature and dose. With a single dose, the effect lasts up to 8 hours. With primary dysmenorrhea, the intrauterine pressure and the frequency of uterine contractions are reduced. Reversibly inhibits platelet aggregation.

Since PG delays the closure of the arterial duct after birth, suppression of COX is believed to be the main mechanism of action of ibuprofen when used w / w in newborns with open arterial duct.

When ingestion is well absorbed from the gastrointestinal tract. Cmax is created within 1 hour, when taken after meals - within 1.5–2.5 hours. Plasma protein binding is 90%. Slowly penetrates the joint cavity, but lingers in the synovial tissue, creating greater concentrations in it than in the plasma. Biological activity is associated with the S-enantiomer. After absorption, about 60% of the pharmacologically inactive R-form slowly transforms into the active S-form. Subjected to biotransformation. There are 3 major metabolites excreted by the kidneys. In unchanged form with urine no more than 1% is excreted. It has a biphasic kinetics of elimination with T1 / 2 from plasma 2–2.5 h (for retard forms, up to 12 h).


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