Hydroxyurea (Гидроксиуреа) 500mg 100 cap

Weight (kg): 0.30

Capsules. The active substance is hydroxycarbamide (Hydroxyurea). Hydroxyurea is a phase-specific cytostatic drug (an antimetabolite, according to some sources, an alkylating action), acting in the S phase of the cell cycle.

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XS 8 4 34 31/32 23/24 33/34
S 10 6 36 33/34 25/26 35/36
M 12 8 38 35/36 27/28 37/38
L 12 8 38 35/36 27/28 37/38
XL 10 6 36 33/34 25/26 35/36

Capsules. The active substance is hydroxycarbamide (Hydroxyurea). Hydroxyurea is a phase-specific cytostatic drug (an antimetabolite, according to some sources, an alkylating action), acting in the S phase of the cell cycle.

It blocks the growth of cells in the G1-S interphase, which is essential for simultaneous radiation therapy, since there is a synergistic sensitivity of tumor cells in the G1 phase to radiation. By enhancing the action of the inhibitor of ribonucleic acid reductase - ribonucleoside diphosphate reductase, it causes suppression of the synthesis of deoxyribonucleic acid. The drug does not affect the synthesis of ribonucleic acid and protein.


- chronic myeloid leukemia;

- true polycythemia (erythremia);

- essential thrombocythemia;

- osteomyelofibrosis;

- melanoma;

- malignant tumors of the head and neck, with the exception of lip cancer (in combination with radiation therapy);

- cervical cancer (in combination with radiation therapy).

Contraindications for use

- leukopenia below 2500/µl;

- thrombocytopenia below 100,000/µl;

- pregnancy;

- the period of breastfeeding;

- hypersensitivity to hydroxycarbamide or any other excipient that is part of the drug.

With caution - with hepatic and / or renal failure, anemia (should be corrected before starting treatment).

Side effect

On the part of the hematopoietic organs: leukopenia, anemia, thrombocytopenia.

On the part of the digestive system: stomatitis, bleeding gums, anorexia, nausea, vomiting, diarrhea or constipation, ulceration of the mucous membrane of the gastrointestinal tract. Increased activity of liver enzymes.

On the part of the skin and skin appendages: macular-papular rashes, facial erythema and peripheral erythema, dermatomyositis skin changes. In some cases, as a result of daily use of the drug for several years, hyperpigmentation, erythema, atrophy of the skin and nails, peeling, and purple papules were observed in patients. In rare cases, alopecia, skin cancer is noted.

From the nervous system: headache, dizziness, fatigue, drowsiness, disorientation; rarely - hallucinations and convulsions.

From the urinary system: an increase in the content of uric acid, blood urea nitrogen and creatinine in the blood plasma, urinary retention, interstitial nephritis. In rare cases, dysuria is noted.

Other: chills, general malaise, increased erythrocyte sedimentation rate, allergic skin reactions, fertility disorders (azoospermia, cessation of menstruation). In rare cases, acute pulmonary reactions associated with the use of the drug have been reported: diffuse infiltration of the lungs, fever and shortness of breath.

Use during pregnancy and lactation

Contraindication: pregnancy and lactation.

Application for violations of liver function

With caution - with liver failure.

Application for violations of kidney function

With caution - with renal failure.

Use in children

The safety and efficacy of hydroxycarbamide in children has not been established.

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