Glivec (Гливек) 100mg 60 tab

€952.63
Weight (kg): 0.30

Capsules. The active substance is imatinib (imatinib). Anticancer drug. Protein kinase inhibitor. Inhibits the enzyme Bcr-Abl-tyrosine kinase at the cellular level, in vitro and in vivo. Selectively inhibits proliferation and induces apoptosis of Bcr-Abl positive cell lines, as well as young leukemic cells in Philadelphia chromosome-positive chronic myeloid leukemia and in acute lymphoblastic leukemia.

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UKUSAEUBUSTWaistHips
XS 8 4 34 31/32 23/24 33/34
S 10 6 36 33/34 25/26 35/36
M 12 8 38 35/36 27/28 37/38
L 12 8 38 35/36 27/28 37/38
XL 10 6 36 33/34 25/26 35/36

Capsules. The active substance is imatinib (imatinib). Anticancer drug. Protein kinase inhibitor. Inhibits the enzyme Bcr-Abl-tyrosine kinase at the cellular level, in vitro and in vivo. Selectively inhibits proliferation and induces apoptosis of Bcr-Abl positive cell lines, as well as young leukemic cells in Philadelphia chromosome-positive chronic myeloid leukemia and in acute lymphoblastic leukemia.

Indications

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) diagnosed for the first time in children and adults; Ph+ CML in the chronic phase with failure of previous therapy with interferon alfa or in the phase of acceleration or blast crisis in children and adults; newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in children and adults in combination with chemotherapy; relapsed or refractory Ph+ ALL in adult patients as monotherapy; myelodysplastic / myeloproliferative diseases associated with gene rearrangements of the platelet growth factor receptor in adult patients; systemic mastocytosis in adult patients with no D816V c-Kit mutation or with unknown c-Kit mutational status; hypereosinophilic syndrome and/or chronic eosinophilic leukemia in adult patients with positive or negative abnormal FIP1L1-PDGRF alpha tyrosine kinase; unresectable and/or metastatic malignant gastrointestinal stromal tumors positive for c-Kit (CD117) in adult patients; adjuvant therapy in adult patients with c-Kit positive gastrointestinal stromal tumors (CD117); inoperable, recurrent and/or metastatic dermatofibrosarcoma bulging in adult patients.

Contraindications for use

Hypersensitivity to imatinib; pregnancy, breastfeeding period; children's age (efficacy and safety have not been established) up to 1 year in patients with Ph + acute lymphoblastic leukemia, up to 2 years in patients with Ph + chronic myeloid leukemia, up to 18 years for other indications.

With caution: patients with severe hepatic insufficiency; patients with severely impaired renal function; patients with diseases of the cardiovascular system or in the presence of risk factors for the development of heart failure; during a regular hemodialysis procedure; when used simultaneously with drugs that inhibit the CYP3A4 isoenzyme, strong inducers of the CYP3A4 isoenzyme. drugs that are substrates of the CYP3A4 isoenzyme; when used simultaneously with paracetamol, warfarin.

Use during pregnancy and lactation

Contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Use with caution in patients with severe hepatic impairment.

Application for violations of kidney function

Use with caution in patients with severe renal impairment.

Use in children

Imatinib is contraindicated under 1 year of age in patients with Ph+ acute lymphoblastic leukemia; up to 2 years in patients with Ph+ chronic myeloid leukemia; up to 18 years for other indications.

Use in elderly patients

Caution should be used in elderly patients.

The highest incidence of fluid retention is observed in elderly patients with concomitant diseases of the cardiovascular system.



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Data sheet

Used in/for
oncology
Release form
Pills
Intended for
Adults

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